![]() ![]() IV Administrationįor solution and drug compatibility information, see Compatibility under Stability.Ĭaffeine citrate is available as a preservative-free injection in single-use vials discard any unused portion. To administer a dose, remove the rubber stopper from the vial and then withdraw and administer the appropriate dose using a 1-mL or other appropriate syringe to ensure accurate measurement. Oral Administration Caffeine Citrate Oral SolutionĪvailable as preservative-free oral solution in single-use vials discard any unused portion. Administer rectally in combination with ergotamine tartrate.Ĭonsult manufacturer’s product labeling for complete directions for appropriate administration of preparations containing caffeine in combination with analgesics, antacids, antihistamines, antipyretics, antitussives, belladonna alkaloids, diuretics, ergotamine tartrate, expectorants, nasal decongestants, skeletal muscle relaxants, sympathomimetics, and vitamins. May need to monitor serum caffeine concentrations periodically during therapy to avoid toxicity.Īdminister orally (caffeine tablets, caffeine citrate oral solution), by slow IV infusion (caffeine citrate), or by slow IV injection or IM or sub-Q † injection (caffeine and sodium benzoate). Prior to initiating caffeine citrate therapy, determine baseline serum caffeine concentrations in neonates previously treated with theophylline (see Specific Drugs and Laboratory Tests under Interactions) and in infants born to mothers who consumed caffeine prior to delivery. Caffeine/Caffeine and Sodium Benzoate Dosage and Administration General Apnea of Prematurity Usefulness is questionable because caffeine’s diuretic activity in patients with fluid retention is minimal. Has been used orally alone and in combination with other drugs (e.g., analgesics, diuretics) to relieve tension, fatigue, and fluid retention associated with menstruation. Safety and efficacy of caffeine citrate in the prevention of sudden infant death syndrome † (SIDS) or prior to extubation in mechanically ventilated infants † not established. Some experts state that the combination of acetaminophen, aspirin, and caffeine is a reasonable first-line therapy for mild to moderate migraine attacks or for severe migraine attacks that previously have responded to NSAIAs or nonopiate analgesics.Ĭaffeine and sodium benzoate injection has been used for the symptomatic relief of headache following spinal puncture †. ![]() Additional studies needed to determine the role, if any, of caffeine as an analgesic adjuvant. ![]() Some evidence that analgesic-caffeine combinations may produce slightly more analgesia than analgesic agents alone and may have beneficial effect on mood however, these results have not always been reproducible in well-controlled studies. Used orally alone and in combination with analgesics (e.g., acetaminophen, aspirin) for treatment of headache, including migraine attacks. However, there is conflicting evidence regarding efficacy of this combination in the treatment of acute migraine attacks. Used in combination with ergotamine to prevent or abort vascular headaches (e.g., migraine and cluster headaches). Use only after other causes of apnea (e.g., CNS disorders, primary lung disease, anemia, sepsis, metabolic disturbances, cardiovascular abnormalities, obstructive apnea) have been ruled out or treated appropriately. Short-term (10–12 days) treatment (as oral or IV caffeine citrate) of apnea of prematurity in neonates who are 28 to <33 weeks of gestational age (designated an orphan drug by FDA for this use). However, most authorities believe caffeine and other analeptics should not be used in these conditions and recommend other supportive therapy because of caffeine’s questionable benefit and transient action. Used in combination with antihistamines to overcome the sedative properties of antihistamines however, efficacy and dosage required not adequately established.Ĭaffeine and sodium benzoate injection has been used in conjunction with supportive measures to treat respiratory depression associated with overdosage of CNS depressant drugs (e.g., opiate analgesics, alcohol) and with electric shock. Used orally as an aid in staying awake and to restore mental alertness in fatigued patients. Uses for Caffeine/Caffeine and Sodium Benzoate CNS Stimulation Written by ASHP.ĬNS stimulant a xanthine derivative. Caffeine/Caffeine and Sodium Benzoate (Monograph)ĭrug class: Respiratory and CNS Stimulants ![]()
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